In a world where superheroes and villains are very real, unassuming office temp Arthur becomes obsessed with a sinister conspiracy he believes has taken over his City. Everyone thinks he's crazy, except his mysterious new ally, The Tick, a bizarre blue superhero who might just be a figment of Arthur's imagination...
Tick and Arthur have a run-in with local villainess Miss Lint and her gang, who will stop at nothing to get back the mysterious supersuit that Tick took from them and gave to Arthur. Dot, Arthur's paramedic sister, moonlights for an unsavory business.
Arthur takes a break from hunting the Terror and tries to get back to his safe, normal, and unheroic life as an accountant unaware he's being stalked by the menacing vigilante Overkill. Tick confesses to an existential crisis.
Tick crashes an Everest family party to convince Arthur's sister Dot of her brother's super-heroic destiny. Another more dangerous party-crasher arrives to threaten Arthur and his family.
Tick and Dot help Arthur try to control his flyaway supersuit as the Pyramid Gang pursues them. Miss Lint has an unexpected caller.
Tick and Arthur try to use Ramses to prove that the Terror is alive and run into trouble. Miss Lint takes the advice of an old friend.
Arthur has a surprising encounter while in The Terror's lair. The Tick attempts a rescue with Dot and Overkill.
Arthur, Dot, and Overkill try to get a message to Superian, with the help of a retired hero.
The Tick and Arthur rush to rescue the endangered Dr. Karamazov. Dot gets some personal information from Overkill.
The Tick and Arthur harbor an out of commission Superian. Dot gathers more intel on the Pyramid Gang, and Overkill confronts Miss Lint.
The team races to counteract The Terror's plan for Big Bismuth and the VLM. Miss Lint and Overkill have something resembling a heart to heart.
The Tick and Arthur find themselves on a final collision course with The Terror as he attempts to bring his evil plans to fruition.